| Primary Identifier | MGI:1919583 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 72333 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable axon guidance receptor activity and cytoskeletal protein binding activity. Acts upstream of or within actin cytoskeleton organization; epithelial cell morphogenesis; and keratinocyte development. Located in Z disc; focal adhesion; and stress fiber. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; heart; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human PALLD (palladin, cytoskeletal associated protein). PHENOTYPE: All homozygous null embryos die around E15.5 displaying exencephaly derived from neural tube closure defects, and herniation of the intestine and liver due to ventral closure defects. Mutant MEFs show impaired formation of actin stress fibers, reduced migration and decreased adhesion to fibronectin. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
