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Protein Coding Gene : Marchf1 membrane associated ring-CH-type finger 1
Primary Identifier  MGI:1920175 Organism  mouse, laboratory
Chromosome  8 NCBI Gene Number  72925
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables ubiquitin protein ligase activity. Involved in antigen processing and presentation of peptide antigen via MHC class II; immune response; and protein polyubiquitination. Located in bounding membrane of organelle; endoplasmic reticulum membrane; and trans-Golgi network membrane. Is expressed in brain; glossopharyngeal ganglion; and spinal cord. Orthologous to human MARCHF1 (membrane associated ring-CH-type finger 1).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal dendritic cell morphology and physiology. [provided by MGI curators]
  • synonyms:
  • RIKEN cDNA 2900024D24 gene,
  • membrane-associated ring finger (C3HC4) 1,
  • MGI:6368844,
  • MGI:2142827,
  • Marchf1,
  • 2900024D24Rik,
  • expressed sequence BB085186,
  • March1,
  • BB085186,
  • membrane associated ring-CH-type finger 1
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