| Primary Identifier | MGI:108082 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 18168 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables pancreatic polypeptide receptor activity and peptide YY receptor activity. Involved in synaptic signaling via neuropeptide. Acts upstream of or within chemical synaptic transmission. Located in membrane and neuron projection. Is active in GABA-ergic synapse and presynapse. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in lipid metabolism disorder and obesity. Orthologous to human NPY5R (neuropeptide Y receptor Y5). PHENOTYPE: Homozygotes for a null allele show increased susceptibility to diet-induced obesity and a reduced orexigenic response to select agonists. Homozygotes for a reporter allele show mild late-onset obesity, increased adiposity, polyphagia, and exacerbated obesity parameters after chronic NPY infusion. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
