Primary Identifier | MGI:97279 | Organism | mouse, laboratory |
Chromosome | 8 | NCBI Gene Number | 17960 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables arylamine N-acetyltransferase activity. Predicted to be located in cytoplasm. Is expressed in several structures, including adrenal gland; brain; genitourinary system; submandibular gland; and thymus. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); contact dermatitis (multiple); leukemia (multiple); and lung disease (multiple). Orthologous to several human genes including NAT2 (N-acetyltransferase 2). PHENOTYPE: Mice homozygous for an ENU-induced allele exhibit reduced fertility and a significant reduction in hepatic N-acetyltransferase 1 activity. [provided by MGI curators] |