| Primary Identifier | MGI:2684762 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 211134 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in regulation of postsynapse assembly. Is active in glutamatergic synapse. Is expressed in several structures, including brain and metanephros. Human ortholog(s) of this gene implicated in breast carcinoma; esophageal cancer; esophagus squamous cell carcinoma; and squamous cell carcinoma. Orthologous to human LZTS1 (leucine zipper tumor suppressor 1). PHENOTYPE: Heterozygous or homozygous inactivation of this gene leads to increased incidence of spontaneous and carcinogen-induced tumors. Homozygtes for a null allele show working memory and cognitive deficits, enhanced anxiety, defects in glutamatergic synaptic transmission, and impaired spine maturation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
