Primary Identifier | MGI:104694 | Organism | mouse, laboratory |
Chromosome | 8 | NCBI Gene Number | 13004 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable calcium ion binding activity; carbohydrate binding activity; and hyaluronic acid binding activity. Involved in modulation of chemical synaptic transmission and regulation of postsynapse organization. Acts upstream of or within regulation of synapse structural plasticity. Is active in GABA-ergic synapse; glutamatergic synapse; and perisynaptic extracellular matrix. Is expressed in lower jaw; nervous system; and sensory organ. Orthologous to human NCAN (neurocan). PHENOTYPE: Mice homozygous for targeted null mutations are viable and fertile and exhibit normal behavior and brain anatomy; however, mild defects in long term potentiation were noted. [provided by MGI curators] |