| Primary Identifier | MGI:2142523 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 382056 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable cAMP response element binding protein binding activity and transcription coactivator activity. Involved in entrainment of circadian clock by photoperiod and positive regulation of CREB transcription factor activity. Acts upstream of or within several processes, including memory; negative regulation of membrane hyperpolarization; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in limb and limb mesenchyme. Used to study major depressive disorder. Orthologous to human CRTC1 (CREB regulated transcription coactivator 1). PHENOTYPE: Mice homozygous for an inactivating mutation in this gene are hyperphagic, obese and infertile. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
