| Primary Identifier | MGI:1340030 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 12931 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable cytokine binding activity and cytokine receptor activity. Predicted to contribute to ciliary neurotrophic factor receptor binding activity and cytokine activity. Involved in negative regulation of motor neuron apoptotic process and ureteric bud development. Located in extracellular space. Is expressed in several structures, including genitourinary system; jaw; limb; respiratory system; and tongue. Human ortholog(s) of this gene implicated in cold-induced sweating syndrome 1. Orthologous to human CRLF1 (cytokine receptor like factor 1). PHENOTYPE: Mice homozygous for a targeted mutation fail to suckle effectively and do not survive beyond 24 hrs after birth. Newborns exhibit reduced numbers of hematopoietic progenitor cells as well as a significant reduction in the number of motoneurons in the lumbar spinal cord and facial nucleus. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
