| Primary Identifier | MGI:1346047 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 23886 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables cytokine activity; hormone activity; and protein homodimerization activity. Involved in several processes, including GDF15-GFRAL signaling pathway; reduction of food intake in response to dietary excess; and regulation of signal transduction. Acts upstream of or within positive regulation of myoblast fusion. Located in extracellular region. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and liver. Orthologous to human GDF15 (growth differentiation factor 15). PHENOTYPE: Homozygous null mice showed no obvious major abnormalities, but exhibit progressive postnatal losses of spinal, facial, and trigeminal motoneurons, accelerated thrombus formation following injury, and decreased bleeding times. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
