| Primary Identifier | MGI:96648 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 16478 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription coregulator binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including cellular response to calcium ion; osteoblast development; and positive regulation of osteoblast differentiation. Predicted to be located in nucleoplasm. Predicted to be part of protein-DNA complex; transcription factor AP-1 complex; and transcription repressor complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and limb. Orthologous to human JUND (JunD proto-oncogene, AP-1 transcription factor subunit). PHENOTYPE: Homozygotes show reduced growth, sensitivity to LPS-induced hepatitis, and male infertility due to hormonal imbalance and impaired spermatogenesis. Targeted cells and mice are sensitive to p53-dependent stress and TNF-induced apoptosis, and show aberrantT cell proliferation and Th2 differentiation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
