| Primary Identifier | MGI:97843 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 19339 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables GTP-dependent protein binding activity and protein-macromolecule adaptor activity. Involved in several processes, including modulation of chemical synaptic transmission; secretion by cell; and synaptic vesicle clustering. Acts upstream of or within several processes, including chemical synaptic transmission; maintenance of presynaptic active zone structure; and synaptic vesicle maturation. Located in several cellular components, including cytoplasmic vesicle; presynaptic active zone; and terminal bouton. Is active in synaptic vesicle membrane. Is expressed in brain and inner ear. Orthologous to human RAB3A (RAB3A, member RAS oncogene family). PHENOTYPE: Homozygous null mutants show impaired synaptic transmission, insulin secretion and glucose intolerance. This mutation and another chemically induced allele affect circadian period and sleep patterns. Heterozygotes show milder circadian rhythm anomalies. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
