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Protein Coding Gene : Ankle1 ankyrin repeat and LEM domain containing 1
Primary Identifier  MGI:1918775 Organism  mouse, laboratory
Chromosome  8 NCBI Gene Number  234396
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable DNA endonuclease activity. Involved in negative regulation of mitotic recombination; regulation of lymphoid progenitor cell differentiation; and regulation of myeloid progenitor cell differentiation. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleoplasm. Predicted to colocalize with nucleus. Orthologous to human ANKLE1 (ankyrin repeat and LEM domain containing 1).
PHENOTYPE: Homozygous inactivation of this gene causes no overt phenotype or detectable defects in hematopoiesis. Mouse embryonic fibroblasts do not show an impaired DNA damage response. [provided by MGI curators]
  • synonyms:
  • Ankrd41,
  • ankyrin repeat and LEM domain containing 1,
  • RIKEN cDNA 8430438L13 gene,
  • Ankle1,
  • 8430438L13Rik,
  • ankyrin repeat domain 41
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