Primary Identifier | MGI:3686743 | Organism | mouse, laboratory |
Chromosome | 8 | NCBI Gene Number | 100037278 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Orthologous to human NIBAN3 (niban apoptosis regulator 3). PHENOTYPE: Mice homozygous for a null allele show impaired B-cell maturation, a reduction of B-1a cells, enhanced survival and proliferation of spleen B cells in response to stimulation, enhanced humoral immune responses, elevated levels of serum IgM and IgG3 antibodies and B-cell expansion in lymphoid organs. [provided by MGI curators] |