| Primary Identifier | MGI:2676364 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 209488 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein-macromolecule adaptor activity. Acts upstream of or within T cell activation; negative regulation of B cell apoptotic process; and negative regulation of mitochondrial depolarization. Located in cytosol and mitochondrion. Is expressed in spleen and thymus. Orthologous to human HSH2D (hematopoietic SH2 domain containing). PHENOTYPE: Mice homozygous for a knock-out allele exhibit enhanced IL-2 production, increased T cell proliferation in response to TCR/CD28 stimulation, splenomegaly, and an increased frequency of activated T cells. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
