| Primary Identifier | MGI:106417 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 27967 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable transmembrane transporter binding activity. Predicted to be involved in intracellular calcium ion homeostasis; positive regulation of calcineurin-NFAT signaling cascade; and release of sequestered calcium ion into cytosol. Predicted to act upstream of or within negative regulation of cell population proliferation. Predicted to be located in sarcoplasmic reticulum membrane. Predicted to be active in perinuclear region of cytoplasm. Is expressed in embryo and extraembryonic component. Orthologous to human CHERP (calcium homeostasis endoplasmic reticulum protein). PHENOTYPE: Mice homozygous for a knock-out allele show abnormal morula morphology and complete embryonic lethality prior to organogenesis. Blastocysts hatch from the zona pellucida but form outgrowths with no defined inner cell mass and few trophectoderm cells after 3 days in culture. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
