| Primary Identifier | MGI:107158 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 20467 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables chromatin binding activity and transcription corepressor activity. Involved in cardiac muscle tissue development; negative regulation of DNA-templated transcription; and skeletal muscle tissue development. Located in several cellular components, including autosome; nucleus; and sex chromosome. Is expressed in several structures, including central nervous system; dorsal root ganglion; eye; genitourinary system; and paraxial mesenchyme. Orthologous to human SIN3B (SIN3 transcription regulator family member B). PHENOTYPE: Homozygous null mice fail to survive past P1 and exhibit pallor, fetal growth retardation, impaired terminal differentiation of erythrocytes and granulocytes, a pale liver and reduced ossification of the long bones in the hindlimb. Mutant MEFs show impaired G0 arrest upon serum deprivation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
