Primary Identifier | MGI:1935129 | Organism | mouse, laboratory |
Chromosome | 8 | NCBI Gene Number | 93762 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and nucleosome array spacer activity. Predicted to contribute to histone binding activity. Involved in negative regulation of macromolecule biosynthetic process and positive regulation of DNA replication. Acts upstream of or within cellular response to leukemia inhibitory factor; chromatin organization; and positive regulation of DNA-templated transcription. Located in nucleus and pericentric heterochromatin. Part of CERF complex; NoRC complex; and chromatin silencing complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human SMARCA5 (SNF2 related chromatin remodeling ATPase 5). PHENOTYPE: Homozygous mutant mice die during early embryonic development. [provided by MGI curators] |