Primary Identifier | MGI:97793 | Organism | mouse, laboratory |
Chromosome | 8 | NCBI Gene Number | 19216 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables D1 dopamine receptor binding activity. Involved in adenylate cyclase-activating dopamine receptor signaling pathway. Acts upstream of or within response to lipopolysaccharide. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and integumental system. Orthologous to human PTGER1 (prostaglandin E receptor 1). PHENOTYPE: Homozygous null mice may exhibit partial prenatal lethality, pain threshold abnormalities, behavioral disinhibition in response to stress, low blood pressure, defects in type IV hypersensitivity reactions, resistance to chemically induced tumors and impaired response to water deprivation. [provided by MGI curators] |