| Primary Identifier | MGI:1344365 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 23863 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables morphogen activity. Involved in determination of left/right asymmetry in lateral mesoderm; heart development; and negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Acts upstream of or within determination of left/right symmetry and negative regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in embryo; gut; node; and primitive streak. Orthologous to human DAND5 (DAN domain BMP antagonist family member 5). PHENOTYPE: Homozygous null mice display partial neonatal lethality with left pulmonary isomerism, abnormal heart looping, atrial and ventricular septal defects and thoracic situs inversus and surviving pups display partial premature death with abdominal organ position abnormalities. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
