| Primary Identifier | MGI:1916974 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 69724 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable RNA-DNA hybrid ribonuclease activity. Acts upstream of or within mismatch repair. Part of ribonuclease H2 complex. Is expressed in several structures, including embryo ectoderm; gut; hemolymphoid system gland; skin; and testis. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome. Orthologous to human RNASEH2A (ribonuclease H2 subunit A). PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased embryo and fetal size and complete perinatal lethality, with innate immune activation of IFN-stimulated genes and decreased susceptibility to viral infection observed in mouse embryonic fibroblasts. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
