| Primary Identifier | MGI:2387588 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 212989 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables bicarbonate channel activity. Contributes to chloride channel activity. Involved in several processes, including bicarbonate transport; chloride transmembrane transport; and sensory perception of smell. Acts upstream of or within chloride transport. Located in basolateral plasma membrane and cilium. Part of chloride channel complex. Is expressed in ovary; submandibular gland; testis; and thymus. Orthologous to human BEST2 (bestrophin 2). PHENOTYPE: Mice homozygous for a null allele exhibit ocular hypotension. Both heterozygous and homozygous null mice show a greater reduction in intraocular pressure following treatment with brinzolamide. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
