| Primary Identifier | MGI:2136825 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 80750 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable RNA nuclease activity; mRNA binding activity; and ubiquitin binding activity. Involved in cellular response to UV; negative regulation of macromolecule metabolic process; and regulation of innate immune response. Located in PML body; cytosol; and nucleolus. Orthologous to human N4BP1 (NEDD4 binding protein 1). PHENOTYPE: Mice homozygous for a null allele exhibit increased activated T cells and germinal center B cells, hyperresponsiveness to TLR1/2, TLR7, or TLR9, and increased sensitivity to induced psoriasis or Pam3csk4 but increased susceptibility to Streptococcus pneumoniae infection. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
