Primary Identifier | MGI:102891 | Organism | mouse, laboratory |
Chromosome | 8 | NCBI Gene Number | 11513 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables adenylate cyclase activity. Involved in cellular response to lithium ion; negative regulation of cytokine production involved in inflammatory response; and regulation of adaptive immune response. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human ADCY7 (adenylate cyclase 7). PHENOTYPE: Mice homozygous for disruptions in this gene display some degree of pre- or postnatal lethality. Surviving adults for one allele appear to be normal. Heterozygous females for one allele display decreased depression related behaviors. [provided by MGI curators] |