| Primary Identifier | MGI:105085 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 19651 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and promoter-specific chromatin binding activity. Predicted to be involved in cell differentiation; negative regulation of G1/S transition of mitotic cell cycle; and regulation of lipid kinase activity. Predicted to act upstream of or within negative regulation of gene expression. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and retina. Used to study lung small cell carcinoma; retinoblastoma; and urinary bladder cancer. Orthologous to human RBL2 (RB transcriptional corepressor like 2). PHENOTYPE: Nullizygous mice generally show no overt phenotype. Homozygotes for a null allele show strain-dependent embryonic lethality and growth arrest associated with altered apoptosis and cell proliferation, impaired neurogenesis and myogenesis, failed embryo turning and heart looping, and thin myocardium. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
