| Primary Identifier | MGI:1347093 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 26383 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables broad specificity oxidative DNA demethylase activity and oxidative RNA demethylase activity. Involved in several processes, including DNA alkylation repair; RNA repair; and regulation of respiratory system process. Located in nucleus. Is expressed in several structures, including alimentary system; cerebral cortex; gonad; hemolymphoid system gland; and liver. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetic neuropathy; nuclear senile cataract; renal cell carcinoma (multiple); and type 2 diabetes mellitus. Orthologous to human FTO (FTO alpha-ketoglutarate dependent dioxygenase). PHENOTYPE: Mice homozygous for an ENU-induced or targeted knock-out allele exhibit decreased body weight, adipose tissue, and body fat and increased metabolism, serum lipids, and serum glucagon that may be gender and diet dependent. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
