Primary Identifier | MGI:1859086 | Organism | mouse, laboratory |
Chromosome | 8 | NCBI Gene Number | 54352 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Acts upstream of or within neuron differentiation; regulation of gene expression; and regulation of heart rate. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; heart; limb; and sensory organ. Orthologous to human IRX5 (iroquois homeobox 5). PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced body size, narrow eye opening, and impaired retinal cone bipolar cell development. [provided by MGI curators] |