Primary Identifier | MGI:1927642 | Organism | mouse, laboratory |
Chromosome | 8 | NCBI Gene Number | 64379 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA-binding transcription activator activity, RNA polymerase II-specific and DNA-binding transcription repressor activity, RNA polymerase II-specific. Acts upstream of or within detection of visible light; regulation of DNA-templated transcription; and retina morphogenesis in camera-type eye. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; endocardial lining; genitourinary system; limb; and retina. Orthologous to human IRX6 (iroquois homeobox 6). PHENOTYPE: Mice homozygous for a null mutation display abnormalities in retinal bipolar cell subtype identity and reduced electroretinography a and b wave amplitudes. [provided by MGI curators] |