| Primary Identifier | MGI:97173 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 17751 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables zinc ion binding activity. Involved in several processes, including leptin-mediated signaling pathway; positive regulation of ERK1 and ERK2 cascade; and positive regulation of metabolic process. Acts upstream of or within intracellular monoatomic cation homeostasis and negative regulation of neurogenesis. Located in synaptic vesicle. Is expressed in several structures, including central nervous system; decidua; dorsal root ganglion; and liver. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human MT3 (metallothionein 3). PHENOTYPE: Mice homozygous for a knock-out allele exhibit a zinc deficiency in several brain regions, abnormal astrocyte morphology, increased susceptibility to kainic acid induced seizures, and altered zinc accumulation and neuronal death in certain brain areas following seizure-induced or acute brain injury. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
