| First Author | Palmiter RD | Year | 1992 |
| Journal | Proc Natl Acad Sci U S A | Volume | 89 |
| Issue | 14 | Pages | 6333-7 |
| PubMed ID | 1631128 | Mgi Jnum | J:1500 |
| Mgi Id | MGI:50027 | Doi | 10.1073/pnas.89.14.6333 |
| Citation | Palmiter RD, et al. (1992) MT-III, a brain-specific member of the metallothionein gene family. Proc Natl Acad Sci U S A 89(14):6333-7 |
| abstractText | A third member of the metallothionein (MT) gene family, designated MT-III, was cloned by virtue of its homology to a human protein that was shown previously to inhibit neuronal survival in culture and to be deficient in the brains of people with Alzheimer disease. Human and mouse MT-IIIs have two insertions relative to all other known mammalian MTs: a threonine after the fourth amino acid and a block of six amino acids near the carboxyl terminus. The genes encoding MT-III resemble all other mammalian MT genes in their small size and exon/intron organization. The MT-III genes are closely linked to the other functional MT genes on human chromosome 16 and mouse chromosome 8. Mouse MT-III gene expression appears to be restricted to brain; in addition, it fails to respond to zinc, cadmium, dexamethasone, or bacterial endotoxin in vivo, thereby distinguishing MT-III from other known MTs. |
