| Primary Identifier | MGI:97171 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 17748 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables copper ion binding activity. Involved in negative regulation of neuron apoptotic process. Acts upstream of or within several processes, including cellular response to chromate; cellular response to zinc ion; and nitric oxide mediated signal transduction. Located in cytosol and lysosome. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; sensory organ; and ventricular layer. Orthologous to several human genes including MT1A (metallothionein 1A); MT1B (metallothionein 1B); and MT1E (metallothionein 1E). PHENOTYPE: Mice homozygous for a null allele exhibit abnormal zinc absorption and abnormal circadian rhythm response to melatonin. Mice homozygous for null alleles of Mt1 and Mt2 exhibit increased sensitivity to xenobiotics and injury with decreased wound healing and abnormal mineral aborption. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
