| Primary Identifier | MGI:1921437 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 74187 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables dynein complex binding activity. Predicted to be involved in several processes, including microtubule cytoskeleton organization; positive regulation of neuron projection development; and regulation of microtubule depolymerization. Located in axon and centrosome. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and primitive streak. Human ortholog(s) of this gene implicated in lissencephaly 6. Orthologous to human KATNB1 (katanin regulatory subunit B1). PHENOTYPE: Nullizygous mice exhibit embryonic lethality, small embryo, brain and limb bud size, variable eye defects, holoprosencephaly, and thin cerebral cortex with fewer cortical progenitors and post-mitotic neurons. Mutant MEFs form multiple centrioles, multipolar spindles, and supernumerary primary cilia. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
