| Primary Identifier | MGI:105057 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 12562 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein phosphatase binding activity. Involved in endothelial cell morphogenesis and regulation of establishment of cell polarity. Acts upstream of or within blood vessel maturation; cell-cell adhesion; and negative regulation of cell population proliferation. Located in several cellular components, including adherens junction; bicellular tight junction; and external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; extraembryonic component; and limb. Used to study exudative vitreoretinopathy. Orthologous to human CDH5 (cadherin 5). PHENOTYPE: Homozygous inactivation or cytosolic truncation of this gene causes embryonic growth retardation, abnormal somite and heart development, impaired remodeling and maturation of endothelial cells, increased endothelial apoptosis and severe vascular defects leading to embryonic death at midgestation. Inducible KO in endothelial cells affects retinal angiogenesis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
