| Primary Identifier | MGI:109200 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 71609 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables signaling adaptor activity. Involved in positive regulation of canonical NF-kappaB signal transduction and positive regulation of hair follicle development. Acts upstream of or within extrinsic apoptotic signaling pathway. Located in cytoplasm. Is expressed in several structures, including adrenal gland; cerebral cortex; genitourinary system; neural tube; and spleen. Orthologous to human TRADD (TNFRSF1A associated via death domain). PHENOTYPE: Nullizygous mutations can cause resistance to toxicity induced by TNF, LPS and poly(I:C), resistance to galactosamine and TNF-induced hepatitis, increased susceptibility to bacterial infection, and impaired formation of follicular dendritic cell networksand germinal centers in spleen. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
