| Primary Identifier | MGI:105975 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 14962 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Predicted to enable serine-type endopeptidase activity. Acts upstream of or within complement activation, alternative pathway. Predicted to be located in cytoplasmic side of Golgi membrane. Predicted to be active in symbiont cell surface. Is expressed in liver lobe. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; eye disease (multiple); glomerulonephritis (multiple); sickle cell anemia; and type 1 diabetes mellitus. Orthologous to human CFB (complement factor B). PHENOTYPE: Homozygotes for targeted null mutations lack the alternative complement pathway, and have reduced overall complement activity. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
