| Primary Identifier | MGI:2148922 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 110147 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables several functions, including C2H2 zinc finger domain binding activity; histone H3 methyltransferase activity; and promoter-specific chromatin binding activity. Involved in DNA methylation-dependent constitutive heterochromatin formation and regulation of DNA replication. Acts upstream of or within several processes, including negative regulation of autophagosome assembly; regulation of gene expression; and response to cocaine. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in idiopathic pulmonary fibrosis. Orthologous to human EHMT2 (euchromatic histone lysine methyltransferase 2). PHENOTYPE: Homozygous mutation of this gene results in embryonic lethality around E9.5-E12.5. Mutant embryos are developmentally delayed. Conditional deletion in germ cells results in infertility and arrest of meiosis. Mice carrying the p.K182R mutation present with increased dexamethasone-induced insulin resistance and insulin levels and reduced dex-induced glucose tolerance. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
