| Primary Identifier | MGI:2685431 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 234695 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable phospholipid binding activity. Acts upstream of or within several processes, including T cell receptor signaling pathway; positive regulation of T cell activation; and positive regulation of cytokine production. Located in cell-cell junction; cytoplasm; and immunological synapse. Part of F-actin capping protein complex. Human ortholog(s) of this gene implicated in immunodeficiency 58. Orthologous to human CARMIL2 (capping protein regulator and myosin 1 linker 2). PHENOTYPE: Mice homozygous for a knock-out or ENU-induced allele exhibit decreased regulatory T cells and reduced proliferative and IL2-secretion response to anti-CD3 and anti-CD28 antibodies. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
