| Primary Identifier | MGI:103296 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 18021 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA-binding transcription activator activity, RNA polymerase II-specific; chromatin binding activity; and transcription cis-regulatory region binding activity. Involved in T cell differentiation in thymus; positive regulation of artery morphogenesis; and positive regulation of biosynthetic process. Acts upstream of or within several processes, including calcineurin-NFAT signaling cascade; cardiac muscle hypertrophy in response to stress; and circulatory system development. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and lung. Orthologous to human NFATC3 (nuclear factor of activated T cells 3). PHENOTYPE: Mice homozygous for disruptions in this gene experience some embryonic lethality and reduced body size. Developmental defects also exist in the immune system , skeletal muscle, vasculature, heart, and sensory nerves. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
