Primary Identifier | MGI:2384879 | Organism | mouse, laboratory |
Chromosome | 8 | NCBI Gene Number | 214572 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables histone H4R3 methyltransferase activity and protein-arginine omega-N symmetric methyltransferase activity. Involved in genomic imprinting. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Is expressed in several structures, including brain and retina nuclear layer. Orthologous to human PRMT7 (protein arginine methyltransferase 7). PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced body weight, increased epididymal fat pad weight, impaired myoblast differentiation, reduced satellite cells, early cellular replicative senescence in muscles and reduced muscle regeneration following injury. [provided by MGI curators] |