| Primary Identifier | MGI:1096573 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 21771 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and regulation of DNA-templated transcription. Predicted to be located in chromosome and fibrillar center. Predicted to be part of small-subunit processome and t-UTP complex. Is expressed in peripheral nervous system ganglion; renal cortex; telencephalon ventricular layer; and thymus primordium. Human ortholog(s) of this gene implicated in cholestasis and primary biliary cholangitis. Orthologous to human UTP4 (UTP4 small subunit processome component). PHENOTYPE: Mice homozygous for a knock-out allele show complete embryonic lethality prior to organogenesis. In vitro, morula-like embryos fail to hatch from the zona pellucida and die after 3 days in culture. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
