| Primary Identifier | MGI:101893 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 18999 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables several functions, including DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and histone H3K56ac reader activity. Involved in blastocyst development; regulation of asymmetric cell division; and regulation of gene expression. Acts upstream of or within several processes, including blastocyst development; cell fate commitment involved in formation of primary germ layer; and regulation of gene expression. Located in cytoplasm; nucleolus; and nucleoplasm. Part of transcription repressor complex. Is active in chromatin and nucleus. Is expressed in several structures, including 4-8 cell stage conceptus; alimentary system; central nervous system; egg cylinder; and gonad. Human ortholog(s) of this gene implicated in embryonal carcinoma and seminoma. Orthologous to several human genes including POU5F1 (POU class 5 homeobox 1). PHENOTYPE: Homozygosity for a targeted null mutation results in peri-implantation lethality prior to the egg cylinder stage, associated with failure to develop a pluripotent inner cell mass. Conditional mutations show defects in reproduction. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
