| Primary Identifier | MGI:1928378 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 56749 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables dihydroorotase activity and dihydroorotate dehydrogenase activity. Involved in 'de novo' UMP biosynthetic process and UDP biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; branchial arch; limb bud; respiratory system; and urinary system. Human ortholog(s) of this gene implicated in postaxial acrofacial dysostosis. Orthologous to human DHODH (dihydroorotate dehydrogenase (quinone)). PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormalities in trophoblast layer formation and complete embryonic lethality during organogenesis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
