Primary Identifier | MGI:1349479 | Organism | mouse, laboratory |
Chromosome | 8 | NCBI Gene Number | 26887 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables N-acetylglucosamine 6-O-sulfotransferase activity. Involved in positive regulation of leukocyte tethering or rolling. Acts upstream of or within leukocyte tethering or rolling and protein sulfation. Predicted to be located in Golgi membrane. Predicted to be active in trans-Golgi network. Is expressed in several structures, including alimentary system; genitourinary system; immune system; liver; and nervous system. Orthologous to human CHST4 (carbohydrate sulfotransferase 4). PHENOTYPE: Mice homozygous for disruptions in this gene do not accumulate lymphocytes in peripheral lymph nodes to as great an extent as normal. The animals are phenotypically normal otherwise. [provided by MGI curators] |