| Primary Identifier | MGI:101914 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 12308 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables calcium ion binding activity involved in regulation of presynaptic cytosolic calcium ion concentration. Predicted to be involved in regulation of long-term synaptic potentiation and regulation of presynaptic cytosolic calcium ion concentration. Located in gap junction. Is active in parallel fiber to Purkinje cell synapse. Is expressed in several structures, including alimentary system; nervous system; reproductive system; respiratory system; and sensory organ. Orthologous to human CALB2 (calbindin 2). PHENOTYPE: Homozygous targeted mutants showed normal growth, normal brain histology, and generally normal behavior. Impaired motor coordination was observed in wheel running in young and old mutant mice, and progressive impairment was seen on the runway and horizontal stationary rod tests in older mice. Abnormalities are observed in Purkinje cell firing, altering both simple and complex spikes. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
