| Primary Identifier | MGI:1921818 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 74568 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables ATP binding activity and protein kinase binding activity. Involved in defense response to virus; execution phase of necroptosis; and necroptotic signaling pathway. Located in cytoplasm; nucleus; and plasma membrane. Is expressed in several structures, including immune system; liver; lung; skin; and telencephalon. Orthologous to human MLKL (mixed lineage kinase domain like pseudokinase). PHENOTYPE: Mice homozygous for a knock-out allele exhibit imapired macrophage and mouse embryonic fibroblast necroptosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
