| Primary Identifier | MGI:2183572 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 170571 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables PDZ domain binding activity. Involved in modulation of chemical synaptic transmission; regulation of grooming behavior; and regulation of synapse organization. Acts upstream of or within neural precursor cell proliferation and neuron differentiation. Located in dendrite and plasma membrane. Is active in GABA-ergic synapse and presynaptic membrane. Is expressed in brain. Orthologous to human CNTNAP4 (contactin associated protein family member 4). PHENOTYPE: Homozygous knock-out mice show increased midbrain dopaminergic release in the nucleus accumbens, synaptic defects, impaired sensory-motor gating, and increased grooming behavior. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
