| Primary Identifier | MGI:106658 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 20807 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and primary miRNA binding activity. Involved in actin cytoskeleton organization; cardiac muscle cell myoblast differentiation; and regulation of miRNA transcription. Acts upstream of or within several processes, including circulatory system development; hemopoiesis; and respiratory system development. Located in chromatin; cytoplasm; and nucleus. Is expressed in several structures, including cardiovascular system; embryo mesenchyme; extraembryonic component; future forebrain; and genitourinary system. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in cardiomyopathy and lymphangioleiomyomatosis. Orthologous to human SRF (serum response factor). PHENOTYPE: Homozygous null mice exhibit embryonic lethality, abnormal gastrulation, no mesoderm or primitive streak formation and reduced embryo size. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
