| Primary Identifier | MGI:87963 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 11606 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables receptor ligand activity; type 1 angiotensin receptor binding activity; and type 2 angiotensin receptor binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; aldosterone secretion; and angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure. Acts upstream of or within several processes, including positive regulation of intracellular signal transduction; positive regulation of metabolic process; and regulation of systemic arterial blood pressure by renin-angiotensin. Located in extracellular space. Is active in extracellular region. Is expressed in several structures, including axial skeleton; central nervous system; foregut mesenchyme; genitourinary system; and liver. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Henoch-Schoenlein purpura; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Orthologous to human AGT (angiotensinogen). PHENOTYPE: Homozygous null mutation of this gene results in small body size and lower body fat, decreased blood pressure and hypotension, kidney abnormalities, polydipsia and polyuria. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
