| Primary Identifier | MGI:107700 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 12363 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables cysteine-type endopeptidase activity and lipopolysaccharide binding activity. Involved in several processes, including non-canonical inflammasome complex assembly; positive regulation of signal transduction; and response to bacterium. Acts upstream of or within ectopic germ cell programmed cell death; positive regulation of interleukin-1 beta production; and positive regulation of macrophage cytokine production. Part of non-canonical inflammasome complex. Is active in cytosol. Is expressed in several structures, including gut; lung; metanephros; reproductive system; and ureter. Orthologous to several human genes including CASP4 (caspase 4). PHENOTYPE: Homozygous mutation of this gene results in decreased levels of serum IL-1alpha and IL-1beta. Mutant animals are resistant to septic shock after injection with LPS. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
