Primary Identifier | MGI:103189 | Organism | mouse, laboratory |
Chromosome | 9 | NCBI Gene Number | 17393 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables peptidase activity. Acts upstream of or within several processes, including defense response to bacterium; proteolysis; and response to xenobiotic stimulus. Predicted to be located in cell surface. Predicted to be active in extracellular space. Is expressed in several structures, including exocrine gland; genitourinary system; hemolymphoid system gland; intestine; and liver and biliary system. Orthologous to human MMP7 (matrix metallopeptidase 7). PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased sensitivity to induced colitis and corneal wound neovascularization, decreased sensitivity to myocardial infarction and pancreatic duct ligation, impaired tracheal wound healing, and altered tumor susceptibility. [provided by MGI curators] |