| Primary Identifier | MGI:97567 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 18667 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables nuclear steroid receptor activity. Acts upstream of or within several processes, including paracrine signaling; progesterone receptor signaling pathway; and tertiary branching involved in mammary gland duct morphogenesis. Predicted to be located in several cellular components, including axon terminus; dendritic spine; and perikaryon. Predicted to be active in nucleus and plasma membrane. Is expressed in central nervous system; genitourinary system; lung; mammary gland; and thymus. Human ortholog(s) of this gene implicated in endometriosis; hyperprolactinemia; and obesity. Orthologous to human PGR (progesterone receptor). PHENOTYPE: Null female mice are sterile and exhibit ovulatory defects, uterine hyperplasia, and impaired mammary development. Females lacking only isoform A are infertile but show normal mammary development, while females lacking only isoform B are fertile but present with mammary developmental defects. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
